Chicken Alfredo Lasagna

Featured in: Weeknight Dinners

Chicken Alfredo Lasagna combines tender shredded chicken with a silky Alfredo sauce, fresh spinach, and layers of melted mozzarella and ricotta cheese between pasta sheets. This Italian-American comfort dish takes 1 hour 25 minutes total and serves 8 people with medium difficulty. Bake at 375°F for 50-55 minutes until golden and bubbly, then let rest before serving for the perfect slice.

Updated on Sun, 18 Jan 2026 14:02:00 GMT
Golden, bubbly Chicken Alfredo Lasagna layers in a white baking dish, steam rising from the melted mozzarella and Parmesan topping. Save
Golden, bubbly Chicken Alfredo Lasagna layers in a white baking dish, steam rising from the melted mozzarella and Parmesan topping. | flashoven.com

The smell hit me before I even opened the oven door. My neighbor had dropped off a pan of something that looked suspiciously unlike any lasagna I'd grown up with. No red sauce, just creamy ivory layers studded with flecks of green and shreds of chicken peeking through the cheese. I reheated a square that night and understood immediately why she'd been making it every other week. It wasn't traditional, but it didn't need to be.

I made this for a book club meeting once, mostly because I'd forgotten to plan anything else. Everyone kept asking for the recipe, and one friend admitted she ate the last cold square straight from the fridge at midnight. That's when I knew it had staying power. It's one of those dishes that makes you look more competent than you feel while you're assembling it.

Ingredients

  • Cooked chicken breast: Rotisserie chicken is your best friend here, it's already seasoned and saves you from poaching or roasting anything extra.
  • Lasagna noodles: Oven ready noodles work beautifully if you add a bit more sauce, but boiling regular noodles gives you more control over texture.
  • Fresh baby spinach: It wilts down to almost nothing, so don't be shy with the amount, and make sure it's cool before mixing or it'll scramble the egg in the ricotta.
  • Onion and garlic: Sautéing these first adds a savory backbone that keeps the Alfredo from tasting flat or one note.
  • Alfredo sauce: Homemade is lovely, but a good jar from the store works perfectly fine and no one will know the difference once it's baked.
  • Whole milk ricotta cheese: The egg helps it set into creamy pockets instead of oozing everywhere, and full fat makes all the difference in richness.
  • Shredded mozzarella cheese: Low moisture mozzarella melts better and won't make your lasagna soupy.
  • Grated Parmesan cheese: Freshly grated has more flavor and melts into a beautiful golden crust on top.
  • Egg: It binds the ricotta layer so it slices cleanly instead of sliding apart on the plate.
  • Dried Italian herbs: A blend of basil, oregano, and thyme adds warmth without overpowering the creamy sauce.
  • Salt and black pepper: Season each layer lightly, the cheeses are already salty so taste as you go.
  • Fresh parsley: A handful of green at the end makes it look intentional and adds a tiny bit of freshness.

Instructions

Product image
Dispense soap hands-free for quick handwashing and easier cleanup while cooking and handling ingredients.
Check price on Amazon
Get the oven ready:
Preheat to 375°F and grease your baking dish so the bottom layer doesn't stick. A little butter or cooking spray does the job.
Prep the noodles:
If you're using regular noodles, boil them until they're just bendable, not fully soft. They'll finish cooking in the oven and you don't want mush.
Sauté the aromatics:
Cook the onion in a bit of olive oil until it's soft and starting to turn golden, then add the garlic and let it bloom for a minute. Your kitchen will smell like an Italian grandmother's house.
Wilt the spinach:
Toss it into the skillet and stir until it collapses and most of the moisture cooks off. Let it cool before mixing or the egg in the ricotta will cook.
Mix the ricotta layer:
Combine ricotta, egg, half the Parmesan, herbs, salt, and pepper in a bowl, then fold in the cooled spinach mixture. It should look like thick, savory cheesecake batter.
Start layering:
Spread a thin layer of Alfredo on the bottom of the dish so the noodles don't stick, then lay down your first four noodles. Overlap them slightly if needed.
Build the first layer:
Spread half the ricotta mixture over the noodles, scatter half the chicken on top, drizzle with Alfredo, and sprinkle with mozzarella. Don't worry if it looks messy, it all evens out.
Repeat the second layer:
Add another four noodles, the rest of the ricotta mixture, remaining chicken, more Alfredo, and another handful of mozzarella. You're almost there.
Finish with the top layer:
Lay down the last noodles, pour the remaining Alfredo over everything, and cover with the rest of the mozzarella and Parmesan. This top layer will turn golden and bubbly.
Bake covered:
Cover the dish tightly with foil and bake for 30 minutes so the noodles steam and soften. The foil keeps the top from browning too fast.
Bake uncovered:
Remove the foil and bake another 20 to 25 minutes until the cheese is golden and the edges are bubbling. If it's browning too quickly, tent it loosely with foil again.
Let it rest:
This is the hardest part, but let it sit for 10 to 15 minutes before cutting. The layers need time to set or your first slice will be a landslide.
Product image
Dispense soap hands-free for quick handwashing and easier cleanup while cooking and handling ingredients.
Check price on Amazon
Fresh spinach and shredded chicken peek through creamy Alfredo sauce between lasagna noodles in this savory Italian-inspired casserole. Save
Fresh spinach and shredded chicken peek through creamy Alfredo sauce between lasagna noodles in this savory Italian-inspired casserole. | flashoven.com

My sister once told me this lasagna reminded her of the kind of meal that makes you want to cancel evening plans and stay in. She wasn't wrong. It's the kind of thing that turns a regular Wednesday into something worth sitting down for, and it makes your kitchen smell like you've been cooking all day even if you haven't. That's a kind of magic worth keeping around.

Picking Your Chicken

Rotisserie chicken from the grocery store is the easiest route and adds a subtle roasted flavor you won't get from plain poached breasts. If you're cooking your own, season it well and let it cool before shredding so you don't burn your fingers. Leftover grilled chicken works too, just make sure it's moist enough or the lasagna can turn a little dry in spots. I've even used turkey in a pinch and no one complained.

Making It Ahead

You can assemble the entire lasagna in the morning, cover it tightly with plastic wrap and foil, and keep it in the fridge until dinner. Let it sit on the counter for about 20 minutes before baking so it's not ice cold going into the oven. If you're freezing it, wrap it well and freeze unbaked, then thaw overnight in the fridge before baking as directed. I've pulled this trick more times than I can count when I needed to look like I had my life together.

Serving and Storing

This pairs beautifully with a simple arugula salad dressed in lemon and olive oil, something bright to cut through all that cream. Garlic bread is always welcome, but honestly it's rich enough to stand on its own. Leftovers keep in the fridge for up to four days and reheat wonderfully in the oven or microwave.

  • Cover individual portions with a damp paper towel when microwaving so they don't dry out.
  • Reheat in a 350°F oven for about 20 minutes if you want the top to crisp up again.
  • Freeze individual slices wrapped tightly in foil for up to three months and reheat straight from frozen.
Product image
Soft, absorbent towels keep counters dry while cooking, wiping spills, and handling dishes during everyday recipe prep.
Check price on Amazon
A slice of homemade Chicken Alfredo Lasagna rests on a plate, garnished with parsley and paired with a green salad. Save
A slice of homemade Chicken Alfredo Lasagna rests on a plate, garnished with parsley and paired with a green salad. | flashoven.com

This is the kind of recipe that earns its place in your rotation without trying too hard. It's comfort food that actually comforts, and it makes enough to share or stash away for the nights when cooking feels impossible.

Recipe Questions & Answers

Can I use store-bought Alfredo sauce?

Yes, store-bought Alfredo sauce works perfectly and saves time. Use 4 cups as specified in the ingredients. Homemade sauce offers more control over flavor and richness if you prefer.

How should I store and reheat leftovers?

Cover and refrigerate leftovers for up to 3 days. Reheat in a 350°F oven for 15-20 minutes covered with foil, or microwave individual portions for 2-3 minutes. Add a splash of milk to restore creaminess if needed.

Can I make this ahead of time?

Absolutely. Assemble the lasagna up to 24 hours in advance, cover tightly, and refrigerate. Bake as directed, adding 10-15 minutes to the covered baking time since it starts cold.

What's the best way to layer the ingredients?

Start with sauce on the bottom, then alternate noodles, ricotta-spinach mixture, chicken, Alfredo sauce, and mozzarella. This ensures even distribution and prevents dry spots. Use 4 noodles per layer for structural integrity.

Are there good substitutions for spinach?

Kale works wonderfully and provides a heartier texture. Zucchini, broccoli, or sun-dried tomatoes also complement the Alfredo sauce beautifully. Chop vegetables finely and sauté until tender before mixing into the ricotta.

How do I know when it's fully cooked?

The lasagna is done when the edges bubble vigorously, the top is golden brown, and a knife inserted in the center comes out hot. The 10-15 minute rest allows the layers to set for cleaner slices.

Chicken Alfredo Lasagna

Rich, creamy lasagna layered with chicken, Alfredo sauce, spinach, and mozzarella for a comforting Italian-American dinner.

Prep Time
30 min
Baking/Cooking Time
55 min
Time Required
85 min
Recipe by Harper Ward

Recipe Type Weeknight Dinners

Skill Level Medium

Cuisine Italian-American

Makes 8 Number of Servings

Diet Considerations None specified

What You’ll Need

Proteins

01 3 cups cooked chicken breast, shredded or diced

Pasta

01 12 lasagna noodles, regular or oven-ready

Vegetables

01 2 cups fresh baby spinach, roughly chopped
02 1 medium onion, finely diced
03 3 cloves garlic, minced

Sauces and Dairy

01 4 cups Alfredo sauce, store-bought or homemade
02 2 cups whole milk ricotta cheese
03 2 cups shredded mozzarella cheese
04 1 cup grated Parmesan cheese
05 1 large egg

Spices and Seasonings

01 1 teaspoon dried Italian herbs
02 1/2 teaspoon salt
03 1/4 teaspoon black pepper
04 2 tablespoons fresh parsley, chopped for garnish

How-To Steps

Step 01

Prepare baking dish: Preheat oven to 375°F. Lightly grease a 9x13-inch baking dish.

Step 02

Cook pasta: If using regular lasagna noodles, cook according to package directions until al dente. Drain and set aside.

Step 03

Sauté aromatics: In a skillet over medium heat, sauté onion in olive oil for 3-4 minutes until softened. Add garlic and cook for 1 minute more.

Step 04

Wilt spinach: Stir in chopped spinach and cook until wilted, about 2 minutes. Remove from heat and let cool slightly.

Step 05

Prepare cheese mixture: In a medium bowl, combine ricotta cheese, egg, half of the Parmesan cheese, Italian herbs, salt, and pepper. Mix in the cooled spinach mixture.

Step 06

Layer base sauce: Spread 1/2 cup of Alfredo sauce on the bottom of the prepared baking dish.

Step 07

Build first layer: Layer 4 noodles over the sauce. Spread half of the ricotta-spinach mixture over noodles. Scatter half the chicken on top. Drizzle with 1 cup of Alfredo sauce and sprinkle with 2/3 cup mozzarella.

Step 08

Build second layer: Repeat with another layer of noodles, remaining ricotta-spinach, remaining chicken, 1 cup Alfredo sauce, and 2/3 cup mozzarella.

Step 09

Add final layer: Top with final layer of noodles, remaining Alfredo sauce, remaining mozzarella, and remaining Parmesan cheese.

Step 10

Initial baking: Cover with foil and bake for 30 minutes.

Step 11

Finish baking: Remove foil and bake an additional 20-25 minutes, until bubbly and golden.

Step 12

Rest and serve: Let stand for 10-15 minutes before slicing. Garnish with fresh parsley if desired.

Essential Tools

  • 9x13-inch baking dish
  • Large skillet
  • Medium mixing bowl
  • Saucepan for homemade Alfredo sauce
  • Measuring cups and spoons
  • Aluminum foil

Allergy Details

Always verify every ingredient for allergens. Talk to a healthcare provider if you're unsure.
  • Contains wheat from pasta
  • Contains milk
  • Contains eggs
  • May contain tree nuts if using nut-based Alfredo sauce

Nutrition per Serving

Details shown are for general reference. Don’t use as a substitute for medical advice.
  • Calories: 510
  • Fats: 27 g
  • Carbohydrates: 33 g
  • Proteins: 34 g